Collies And Other Herding Breeds At Higher Risk For Toxic Effects Of Antiparasitic Drug Ivermectin

Ivermectin is an antiparasitic drug used to treat many different parasites in dogs. Collies and other herding breeds have a MDR1 mutation. This puts them at higher risk for toxic effects if given at higher dosages. The increased sensitivity of these breeds is a result of a mutation of the MDR 1 (Multi-drug resistance) gene. Not every collie and herding dog has this mutation. On average, about 70% of collies in the US have the mutation. Dogs with sensitivity to IverMectin can show symptoms of toxicity within 4 to 6 hours of exposure. These include: Neurologic signs: These are the most serious and concerning side effects dogs may experience. Dogs may also drool. Your dog will be able to feel the symptoms your dog is experiencing. This will include supportive care like giving your dog fluids, other drugs and supplemental oxygen. . . .